BACKGROUND: Although the human genome database has been completed a decade ago, approximately 50% of the proteome remains hypothetical as Frosted Glass Cup their functions are unknown.The elucidation of the functions of these hypothetical proteins can lead to additional protein pathways and revelation of new cascades.However, many of these inferenc
In closed systems, dynamical symmetries lead to conservation laws.However, conservation laws are not applicable to open systems that undergo irreversible transformations.More general selection rules are needed to determine whether, given two states, the transition from one state to the other is possible.The usual approach to the problem of finding
Recent research suggests that in some West German regions, single-family housing (SFH) neighbourhoods are prone to decay due to changed socio-economic and demographic trends.The question of whether similar demographic trends and implications for the SFH stock can be described for other West European countries such as Belgium, France, Netherlands an
To accelerate new drug, biologic, and medical device development and to improve efficiency of delivery of the latest breakthroughs of innovative, life-saving treatments to millions of patients, single-arm trial (SAT) applications of rare diseases or conditions supplemented by their external control arm (ECA) evidence for regulatory approvals have b